Erratum: Stabilizing prospects for a universal flu vaccine

Strategy for approving a universal flu vaccine

Prospects for Universal Influenza Virus Vaccine

The current vaccination strategy against influenza A and B viruses is vulnerable to the unanticipated emergence of epidemic strains that are poorly matched by the vaccine. A vaccine that is less sensitive to the antigenic evolution of the virus would be a major improvement. The general feasibility of this goal is supported by studies in animal models that show that immunologic activities direct...

Prospects of HA-Based Universal Influenza Vaccine

Current influenza vaccines afford substantial protection in humans by inducing strain-specific neutralizing antibodies (Abs). Most of these Abs target highly variable immunodominant epitopes in the globular domain of the viral hemagglutinin (HA). Therefore, current vaccines may not be able to induce heterosubtypic immunity against the divergent influenza subtypes. The identification of broadly ...

The quest for a H1N1 flu vaccine.

Rationing the flu vaccine.

In October 2004, the CDC announced that Chiron Corporation, chief supplier of inactivated influenza vaccine for the United States for the 2004–2005 flu season, would not be providing the 50 million vaccinations it had promised—half of the anticipated 90–100 million doses from all sources projected for the flu season. The resultant shortage set off a firestorm of concern. Well known to health ca...